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26 Through mediating the post-translational modification dependent on NAD + , sirtuins modulate the adaptation to the altered cellular energetic status, especially the activation of oxidative metabolism and stress resistance in mitochondria in various physiological or pathological conditions

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That means eating foods that are rich in animal proteins, which are the main source for B12: Vegans and vegetarians who dont eat animal products may include a B12 supplement in their diet

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