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Exogenous testosterone actually works to inhibit the production of other fertility hormones, significantly impairing or even halting sperm production altogether

Through multi-target mechanisms, these active metabolites either directly activate the -catalytic subunit of AMPK (via phosphorylation at Thr172) or indirectly modulate upstream kinases (such as LKB1 and CaMKK ), thereby influencing the expression and activity of downstream key effector molecules, including ACC, SREBP-1c, and PPAR

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Injury of macrophages induced by Clostridium perfringens type C exotoxins

Nature 547 , 453457 (2017)

Collectively, MO could attenuate the negative impact of the chronic inflammation mainly through inhibiting the expression of a series of pro-inflammatory factors