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Related to this, -KG contributes to redox homeostasis by replenishing the TCA cycle as an intermediate metabolite 19 and controls GLUT1 transcription during glucose limitation as a signaling molecule 21

The ability of this complex depends on ligand-induced activation of both the VDR and RXR, reflecting a dual-ligand requirement for effective transcriptional regulation ( Physiologically, vitamin D plays a central role in calciumphosphate homeostasis and bone metabolism

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