Interestingly, berberine nanoparticle-treated GDM rats demonstrated a significant elevation in fasting insulin levels, where a 2.75-fold and 2.4-fold elevation in fasting insulin was found in GDM rats treated by berberine nanoparticles at the low and high doses, respectively, in comparison with those treated by free berberine
Targeted analysis was carried out on Dionex UltiMate 3000 nanoRSLC coupled to a TSQ Altis mass spectrometer (Thermo Fisher Scientific, San Jose, CA, USA) equipped with a nanoelectrospray ion source
Antioxidant supplementation is another approach used to counteract the effects of leukocyte-derived ROS
Mitochondria are both the major source of ROS production and a target for OS
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