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A 2025 systematic review in the American Journal of Sports Medicine confirmed preclinical support across tendon, ligament, muscle, and bone repair models while explicitly noting the absence of human clinical trial data (DOI: 10.1177/15563316251355551)

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One study on Italian healthcare workers suggested that half of them used reusable bottles, while research involving university students suggests somewhere between 50% and 81% of participants used these drinking vessels

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