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Results Administration of exogenous melatonin alleviates allergic airways disease severity in allergen-exposed mice Given the growing evidence linking circadian disruption to increased severity of allergic asthma ( Alternaria alternata (AA) or PBS daily for four days, with or without concurrent intraperitoneal melatonin treatment using established protocols described previously ( Figure 1A )

(Lond.) 17 , 33 (2020)

doi: 10.1186/s13075-015-0539-z 80 LopezPRodriguez-CarrioJMartinez-ZapicoAPerez-AlvarezAILopez-MejiasRBenaventeLet al

Second, radiographic imaging revealed mid-to-late-stage bone changes associated with OA (Fig