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As this next slide shows, this was very deliberate

Effects of thrombin on neurogenesis after intracerebral hemorrhage

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In addition, it is thought that the mechanisms that ensure PQC in the nucleus are distinct from those of other organelles [108, 109], an example being the exclusive use of K48-linked ubiquitin chains required for proteasomal degradation of misfolded proteins, and thus independency of K11-specific ligases and chaperones [110]

There was no significant difference in the proportion of patients receiving oxygen therapy ( p = 1.000), antiviral therapy ( p = 0.708), antibiotics ( p = 1.000), and intravenous corticosteroids therapy ( p = 0.06) between the two groups

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