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However, most of this research has been conducted in animal models, and human safety and efficacy data are limited

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A landmark 2003 study in the Journal of Physiology and Pharmacology examined rats with completely transected Achilles tendons

[3][4] Research has examined T4 (and its TB-500 fragment) in the context of: Cell migration at wound margins Corneal and dermal wound healing in preclinical models [5] Cardiac repair following ischemic injury an area of active investigation Hair follicle stem cell migration Anti-inflammatory modulation The active 17-amino-acid sequence is well-characterized, and synthetic TB-500 is widely used in research as a stable proxy for full-length T4 protein