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The rationale, design and baseline data of FLOW, a kidney outcomes trial with once-weekly semaglutide in people with type 2 diabetes and chronic kidney disease

Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis: a forty-eight week, multicenter, randomized, double-blind, placebo-controlled study

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2011 Sep;94(3):84753

Also, some cohort studies lacked detailed exposure intensity and duration data or were unable to evaluate cumulative effects over extended periods 273

However, this is a mixed observation, and careful monitoring in research protocols is key