Among lncRNAs, MALAT1, lincRNA-p21, TUG1, and H19 have been identified as key modulators: MALAT1 associates with UVB-induced senescence and photoaging in dermal fibroblasts and may have analogous roles in melanocytes, while lincRNA-p21 mediates p53-dependent apoptosis and cell cycle arrest to prevent malignant transformation 107
It is a very potent anti-inflammatory agent, secreted as part of the inflammatory response
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doi: 10.3389/fnins.2021.584649 Received 17 July 2020 Accepted 04 March 2021 Published 11 May 2021 Volume 15 - 2021 Edited by Marco Solmi, University of Padua, Italy Reviewed by Kenji Hashimoto, Chiba University, Japan