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RCT evidence: A: Robust replicated results from at least 2 large long-term double-blind RCT, ideally with confirmation from a systematic review or meta-analysis B: Supporting evidence from the primary outcome of at least one large long-term double-blind RCT C: A lack of supporting evidence from the primary outcome of a large long-term double-blind RCT but promising results from either small pilot RCTs or from post-hoc and planned secondary analyses

The only element of identification is the ministerial code MINSAN

Fibroblasts are central to collagen, elastin, and matrix protein production, making them a key focus in wound-repair and structural-aging research

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These mechanisms plausibly influence behavioral domains (irritability, hyperactivity, sociability, language, sleep) and interact with gastrointestinal comorbidities and barrier integrity

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