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In particular, the pathways involved in the metabolism of alanine, -alanine, aspartate, cysteine, histidine, glutamate, methionine, nitrogen, and nicotinate/nicotinamide, as well as the biosynthesis of acetyl-CoA are repressed

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However, in aralar / animals de-amidation of glutamine in neurons may be impaired as will be discussed below, which may prevent glutamine synthesis in astrocytes