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Importantly, Gclc -deficient FoB accumulate ROS (Fig

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Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels

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They also do a sort of clean up duty, they recognize, breakdown and remove oxidized or damaged proteins, DNA and lipids, to prevent their accumulation which can be toxic to body tissues