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AQP4 on astrocytic end-feet relocates towards the soma, causing astrocyte swelling, capillary compression, and decreased CBF [95,96,97]

In brief, isolated cells were lyzed in 500 L Qiazol following sorting, 100 L chloroform were added and samples spun at 2500 g for 15 min at +4 C in a MaXtract column (Qiagen, Venlo, Netherlands)

Primarily, the redox state of these thiol groups is controlled by the oxidoreductases of the thioredoxin (Trx) family, to which Trxs, glutaredoxins (Grxs), and peroxiredoxins (Prxs) belong [1,2]

CagriSema's 20.4% mean weight loss on ITT analysis (22.7% on-treatment) means: ~60% of participants lost 20% body weight

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