The N-terminal domain of GSDMD (GSDMD-NT) has high affinity for acidic phospholipids, phosphatidylserine, and cardiolipin, which are rich in the inner leaflet of the plasma membrane and in the mitochondrial membrane (80)
10.1039/C3MT00185G 263
Aside from declining with age, reduced glutathione can also be caused by stress, poor nutrition, and exposure to certain toxins
Fernndez-Blanco JI, Fernndez-Daz G, Cara C, Vera MI, Olivares D, Taxonera C
This rapid clearance is primarily due to swift enzymatic degradation by peptidases in the bloodstream
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