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This triple-agonist mechanism is what makes it potentially more effective than single-agonist peptides like semaglutide , but it also means the gastrointestinal side effects can be more intense if you start too high

Gut-specific improvements may take 48 weeks as overall inflammation decreases

5 They are crucial players in cell signaling 6 and while detoxifying, specific GST classes, particularly pi and mu, directly interact with signaling molecules like c-Jun N-terminal kinase 1 (JNK1) and apoptosis signal-regulating kinase (ASK1)

doi: 10.1038/s41419-023-06300-2 71 HuangYPWangYXZhouHLiuZTZhangZJXiongLet al

W., Tschp, M

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