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Recent research has shown that the increased expression of the glutamine (Gln) transporter SNAT2/SLC38A2 in TNBC bolsters the cells' ability to uptake Gln and withstand oxidative stress
Blockade of PD-L1 palmitoylation with 2BP, siRNA knockdown of zDHHC3 or a competitive, cell-penetrating disruptor peptide that prevented palmitoylation of PD-L1 by zDHHC3 promoted anti-tumor immunity in vitro and inhibited tumor growth in vivo , providing a new strategy for targeting PD-L1-dependent tumor immune escape (185)
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All figures are cited for research-use-only reference and are not medical or dosing guidance
Another study reported that Treg cells impaired mitochondrial oxidative phosphorylation during an autoimmune process (58)