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Separate studies showed that MOTS-c injection into areas with implanted UHMWPE (ultra-high molecular weight polyethylene) particles prevented significant bone mass loss and reversed existing bone loss

By reducing the levels of these hydroperoxides, GPX4 inhibits the formation of more reactive and damaging lipid radicals, particularly protecting cells with membranes rich in PUFAs, which are highly susceptible to peroxidation (143,146)

This innovative peptide works by disrupting the interaction between FOXO4 and p53 proteins within senescent cells

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Nutritional and lifestyle interventions A nutritionally optimized diet coupled with a balanced lifestyle exerts indispensable immunomodulatory effects through the potentiation of innate and adaptive immune responses, as well as the attenuation of chronic low-grade inflammation (inflammaging)

This alteration in AMPA receptor dynamics can further contribute to the impairment of LTP, as the activation of AMPA receptors is essential for the stabilization of LTP following its induction (Gerace et al