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Currently developed DPP1 inhibitors are all oral formulations, while many NSP inhibitors require inhalation administration ( However, DPP1 inhibition also has some potential disadvantages, including slower onset (approximately 20 days to achieve maximum effects) and possible systemic side effects such as hyperkeratosis and periodontitis

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The most common side effects are nausea, vomiting, diarrhea, and constipation

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The XP GScore values obtained from ensemble docking and the experimental inhibition values (IC50) of the compounds in key clusters were used to design an affinity score to rank the compounds in each cluster according to their experimental and computer-predicted inhibition capacities