Compared with GPX1-3, GPX4 is also involved in the reduction of complex membrane-associated phospholipid hydroperoxides such as phosphatidylcholine hydroperoxide and cholesterol hydroperoxide, in addition to reacting with soluble, low molecular weight hydroperoxides such as t-butyl hydroperoxide and cumene hydroperoxide [68]
It is present in cells in two forms: reduced, known as GSH, and oxidized as GSSG (glutathione disulfide) (42)
The kinetic data can be best explained by a ternary complex in which PfGrx recruits and activates GSH at the 1st glutathione-interaction site to facilitate the rate-limiting glutathionylation of roGFP2 WT (S 2 ) and its subsequent deglutathionylation in accordance with monothiol mechanism (iii) from Fig
It oxidizes into glutathione disulfide (GSSG), where the SS denotes the disulfide bond between two glutathiones
Moreover, we emphasize GSH system-related ferroptosis in cardiac injury events and comprehensively summarize strategies for GSH system activation
Mechanisms of hypoxemia
