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45, 46 A detailed analysis of the inflammatory infiltrates in a mouse model of chronic obstructive pulmonary disease (COPD) revealed that DC numbers in the airways raised gradually after a short period of continual smoking, reaching 10-fold levels after a chronic exposure for 6 months compared with the numbers in sham-exposed animals

It might be difficult to articulate with a mouth filled with a large ring gauge cigar

[25] Providing information does not generally provoke reactance

If I smoke, it's a pack a week

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#5: Knackered To be knackered means to be extremely tired or exhausted