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Oral CO administration activated signaling cascades mediated by heme oxygenase-1 (HO-1), which have been implicated in limiting oxidative stress, and in promoting Syn degradation, thereby conferring neuroprotection

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These mechanisms are essential for proper cell function and are widely recognized as fundamental for cell signaling involved in aging, cell proliferation and cell death

It is also interesting that maternal smoking affects fetal growth more in the male than the female fetus