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Patients should discontinue tirzepatide and seek immediate medical attention if they experience difficulty breathing, facial or throat swelling, severe rash, or rapid heartbeat

This process is closely associated with autophagy, particularly with NCOA4-mediated ferritinophagy

10.1371/journal.pone.0201369 48 HirschhornT.StockwellB

Efficacy figures are averages, not individual guarantees, and long-term data continue to mature

In addition to the PERK-ATF4-CHOP axis, other key ER stress pathways, such as IRE1/XBP1 and ATF6 also contribute to the UPR, collectively managing protein misfolding and restoring homeostasis, or, if stress persists, trigger cell death (Tabas and Ron, 2011)