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doi: 10.1016/S0899-5885(02)00096-5 177 FabianiMESourialMThomasWGJohnstonCIJohnstonCIFraumanAG

doi: 10.1016/j.fochx.2022.100437 237 SamantaSSarkarTChakrabortyRRebezovMShariatiMAThiruvengadamMet al

The difference is more significant than most people realize

RAS overactivation is involved in oxidative stress via increasing Ang II levels and oxidative stress in the central nervous system is associated with depression (126) ( Figure 1B )

However, due to the lack of extensive human clinical trials, precise information on its half-life and how long it remains active in the system is not clearly established

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