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Lu, N., Jun, J

Currently, limited evidence supports a direct role for trained immunity in sarcoidosis, However, some studies suggest that monocytes in sarcoidosis patients exhibit pathological features overlapping with the detrimental effects observed in trained immunity

Wu B, Chen Y, Chen Y, Xie X, Liang H, Peng F, et al

This paradox may be explained by the increased insulin resistance and the compensatory intra-portal hyperinsulinemia causing increased hepatic GH sensitivity that increases serum IGF-I and blunts pituitary GH secretion via the negative feedback loop

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