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Besides its use as a local and topical anesthetic agent, lidocaine is used to treat ventricular arrhythmias, principally ventricular tachycardia and ventricular premature complexes in all species

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A smaller proportion is oxidised by phase I reactions catalysed by mixed function oxidases (cytochrome P450, CYP450), nicotinamide adenine dinucleotide phosphate oxidase and oxygen [13, 17]

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[DOI] [PubMed] [Google Scholar] 163.Ertunc ME, Sikkeland J, Fenaroli F, Griffiths G, Daniels MP, Cao H, et al