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However, while the effect of IR on GPX4 activity may vary by cell type, it is well established that increased GSH and GPX4 levels are protective against IR-induced ferroptosis in both healthy and malignant cells [35, 51, 56, 57]

Conceptual schematic illustrating the attenuation of circadian rhythm amplitude and phase shifts in aging, with a particular emphasis on nocturnal melatonin decline as a central driver of sleep fragmentation, metabolic dysregulation, and reduced antioxidant capacity ( The figure highlights age-related changes in key physiological variables, including restactivity cycles, core body temperature, hormonal secretion (melatonin and cortisol), suprachiasmatic nucleus (SCN) neuronal activity, and metabolic indicators such as glucose regulation

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10.31193/ssap.01.9787509752807 351

Structural Chemistry and Biology of Manganese Metalloenzymes

10.1016/j.cbpc.2021.109151 101 WangX.WangR.XingD.SuH.MaC.DingY.et al (2005)