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Importantly, these changes in mitochondrial mass are not related to engagement of apoptosis: inhibition of caspase activity using zVAD-fmk did not prevent increases in mitochondrial abundance per cell (Extended Data Fig

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Protocols shorter than 4 weeks may be suitable for examining acute effects or early adaptations but are unlikely to capture the full magnitude of IGF1 LR3s effects on muscle growth or body makeup

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