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All mice were housed under a 12 h light/dark cycle, with the temperature consistently maintained between 18 C and 23 C and the humidity kept at ~50%
The mechanism of this interaction remains unclear
It increases the number of synaptic vesicles at the presynaptic terminal, boosts postsynaptic receptor responsiveness, and increases the overall number of synapses per neuron
Conversely, inhibition of MEK1/2 by MEK1/2 inhibitor (U0126) or knockdown of MEK1 and MEK2 by corresponding mek1 and mek2 siRNA enhanced AKT phosphorylation, indicating mutual inhibition between AKT and MEK
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