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At the same time, indoleamine 2,3-dioxygenase-1 (IDO1) siRNA was delivered to tumor-draining lymph nodes (TDLNs) and tumor tissues via cationic lipid-assisted nanoparticles (CLAN), the results showed that co-administration of oxaliplatin and CLAN-siIDO1 could achieve a synergistic anti-tumor effect by increasing the number of infiltrating T lymphocytes and reducing the number of Tregs (147)

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TGF drives NK cell metabolic dysfunction in human metastatic breast cancer