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UGT74F2 T15V has reduced specific activity for SGE formation compared to wild-type UGT74F2 (by ~33%), but is still specific for SGE as it forms negligible SAG (Fig

Moreover, decreased TMAO urine excretion is associated with high salt dietary intake, increasing plasma TMAO concentration [82]

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Milaneschi Y, Arnold M, Kastenmller G, Dehkordi SM, Krishnan RR, Dunlop BW, et al