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(8) Furthermore, FOXO4's role in the IIS pathway suggests it might modulate the actions of diet and environmental factors on cell aging, acting as a mediator between external factors and cellular longevity pathways

The public evidence currently supports the first much better than the second

[86] Phosphodiesterase inhibitors (PDE) [edit] A 2018 Cochrane review of studies on men over 60 with moderate to severe lower urinary tract symptoms analyzed the impacts of phosphodiesterase inhibitors (PDE) in comparison to other drugs

It may actually accelerate it

Artificial intelligence and digital health have real potential here