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Parasitology 144 (2), 117123

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Injections: Results can be seen within 1 to 3 months of treatment, with consistent weekly or bi-weekly injections

Because the elongation enzymes prefer the monomer Ub to the Ub chain, Ub (K48R) modifies four K48 residues of K29-Ub4 in the major reaction to synthesize K29/K48-Ub8

Native rhIGF-1 (mecasermin, brand name Increlex) is FDA-approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or with GH gene deletion who have developed neutralizing antibodies to GH