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Louis have used click chemistry to link a second antibody to a pre-existing antibody-drug conjugate (ADC) in vivo

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This direct administration method offers distinct advantages for specific populations and circumstances

Bioavailability limitations require 2-3x higher doses for nasal versus injectable delivery , creating corresponding 2-3x cost increases that make nasal spray primarily appropriate for needle-phobic individuals or peptides specifically designed for nasal use

Another side effect is a temporary increase in blood sugar

57(Suppl 6): 17-42