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According to Li et al

These dUTPase proteins, along with other viral dUTPases such as HSV-1 and HHV-6, are thought to promote cellular damage and promote autoimmune features, as well as promoting mitochondrial fusion and decreasing energy production (127)

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It is clinically characterized by delayed cerebral development, cataracts, craniofacial flattening, ear and nasal deformities, delayed tooth eruption accompanied by morphological abnormalities, hearing loss, short stature, scoliosis, knee valgus, valgus foot deformity, and delayed epiphyseal development [77]