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Lee J, Jeong J, Nguyen VP, Hong S, Paulus YM, Lee CH

Supplementation with 300-600 mg/day has been shown to increase intracellular glutathione levels by 30-70% in cell culture and animal studies, with more modest increases in human trials (Suh et al., Proc Natl Acad Sci, 2004) [25]

Ruptures of the endosomal membrane have been improved by pH-sensitive nanocomposites to allow the release of the drug straight into the cytosol thereby improving the therapeutic effect of the drug [136]

[Abstract] Angew Chem Int Ed Engl

Interpretation of the findings is difficult because data was only provided for the 'responder' subgroup and this did not include standard deviations or units for plasma GSH or GSH:GSSG, nor did it state whether the GSH values reported in Figure 4 of their paper represented tGSH or reduced glutathione