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Perilipin-null mice also display a significant resistance to diet-induced obesity (78, 106, 127) that is explained, at least in part, by increased beta-oxidation of fatty acids, the products of lipolysis (106), following from a compensatory induction of genes involved in lipid and energy metabolism and a downregulation of genes involved in lipid biosynthesis (20)

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Keywords: adipocyte, lipolysis, triacylglyceride lipase, perilipin, desnutrin/ATGL, hormone-sensitive lipase INTRODUCTION White adipose tissue (WAT) triacylglycerol (TAG) is the major energy reserve in higher eukaryotes

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