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Studies have demonstrated low blood levels of ergothioneine in patients with mild cognitive impairment and dementia [7-9]

As we age, NAD+ levels tend to decline, which is why it has become a focus of longevity research

Clin Psychol Rev 3:393407

There are also strains under development that have been genetically engineered to secrete immunomodulators, which have the potential to favorably influence the immune system

Indications of vitamin deficiency may include Fatigue Bone pain Muscle weakness Muscle aches Muscle cramps Poor sleep Depression or feelings of sadness Hair loss Loss of appetite Increased susceptibility to illness You should undergo vitamin level testing and take appropriate measures if your levels are low

Whitburn J, Edwards CM, Sooriakumaran P (2017) Metformin and prostate cancer: a new role for an old drug