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Because it influences so many fundamental biological pathways, its introduction into a system that is already compromised can have significant, sometimes catastrophic, consequences

Why does it work

Proc Natl Acad Sci USA, 2008

The PCs are synthesized by the phytochelatins synthase (PCS) gene that responds under HMs stress

Accumulated cellular iron generates cytotoxic hydroxyl radicals (OH) via the Fenton reaction

112 Like other gastrointestinal peptides, GLP-1 is also produced in the CNS, 113 particularly the nucleus of the solitary tract (NTS) and hypothalamus, with high levels of GLP-1 receptor mRNA present in ARC and PVN