BDCMs possess four main structures: zero-dimensional (0D) (Sun et al
2022;46:e14382
Lipopeptides can form self-assemblies (micelles, vesicles) that affect bioavailability Study pathways: in vitro, ex vivo, in vivo Cell cultures Primary fibroblasts (neonatal, adult, senescent) on 2D collagen-coated or 3D scaffolds Keratinocytes HaCaT or primary for barrier and pigmentation studies (melanocyte co-culture) Skin equivalent models : EpiSkin, Phenion, reticulated skin (raft cultures) Ex vivo Human skin explants (plastic surgery) maintained in interface culture 7-14 days Organotypic perfusion of porcine skin, frequent model for penetration studies In vivo Murine wound models : 6 mm dorsal excisional wound, kinetic closure measurement Photoageing : SKH-1 hairless under chronic UV-B, wrinkle quantification by optical profilometry Diabetes (db/db): delayed healing, efficacy model for GHK-Cu Porcine models : skin close to human, used for clinical translation studies Research dermatological peptides FAQ Why is a native tripeptide (GHK) active
Myth: You can't take glutathione at night because it will keep you awake
Fight Acne and Bacteria Catechins and tannins in white tea extracts are great antibacterial and acne-busting compounds
Anti-inflammatory properties to reduce inflammation
