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Nonetheless, higher doses (2,7004,500 mg/kg) induced some behavioral changes in rats, such as aggressive scratching, anorexia, mild restlessness, and increased sensitivity to sound

Conversely, abundant leucine activates mTORC1 through Sestrin2-GATOR2 dissociation 390 , illustrating how individual nutrients can bypass insulin signaling

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The pharmacokinetics of retatrutide are dose-proportional, with a half-life of approximately 6 days, making weekly dosing feasible [113]

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