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Preclinical research has shown encouraging impacts on metabolic function and fat reduction without requiring major dietary adjustments

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Metabolism in mammals is highly efficient, designed to maximize energy yield from available calories

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Diet, supplements (e.g., niacin, NR), and exercise help, but may not suffice post-40 due to inefficiency and depletion.[18][19] Oral precursors like NMN increase NAD+ but bioavailability varies