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Human placenta extract contains bioactive compounds that stimulate tissue regeneration

It is now evident that dysfunction of this pivotal antioxidant pathway plays a central role in the pathogenesis of diabetes and its diverse complications [8587] (Figure 2)

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755 Mechanistically, SSAT1 overexpression increases ALOX15 expression and decreases the expression levels of GPX4 and SLC7A11 in primary cortical neurons, suggesting that SSAT1/ALOX15 axis activation may aggravate brain I/R injury by triggering ferroptosis in neurons

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These studies confirm that skeletal muscle is both a sink and source for IGF-I, and this raises the possibility that enhancing either production or retention of IGF-I in this tissue could lead to increased muscle mass