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426 Children with autism have defects in mesolimbic dopaminergic signalling, such as decreased dopamine release in the prefrontal cortex and decreased NAc neural responses

However, the total area under the curve (AUC), which represents overall drug exposure, remained comparable regardless of site

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The risks of implant surgery may include bleeding, infection (1-2% of patients during the healing process), and in rare cases erosion of the implant, device malfunction, need for revision surgery, pain, cosmetic dissatisfaction, perforation of the urethra, or severe bowel/bladder/vascular injuries