aspirin and glutathione Acetaminophen aspirin toxicity are both high-yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is It has an acetyl group (COCH3) attached to the sulfur atom of cysteine in the glutathione molecule In Vitro Kinetic of Glutathione-S-Transferase
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