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23 Folate insufficiency also leads to high levels of homocysteinean amino acid produced when proteins break down, and a risk factor for adverse pregnancy outcomes, including NTDs, miscarriage (the most common complication of early pregnancy), preeclampsia, preterm birth, and poor fetal growth

Enriched OMs were pelleted by centrifugation (10 min 50,000 g ) and re-suspended in Tris buffer at a concentration of 0.1 g/ml

The most common is mild injection site reaction (redness or itching), which typically resolves within a day

26 , 1690.e11690.e4 (2020)

It is most common in the big toe, and is also common in the midfoot, ankle, and knee

Extracting peptides while removing interfering substances is essential for accurate detection