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Pre-mixed vials lock the ratio they cannot be used during the staged titration described above without overdosing one component or underdosing the other

In a 9-month monkey oral toxicity study, all female monkeys in the high-dose group showed minimal-to-slight periportal hepatocyte vacuolation

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169 In Staphylococcus aureus , Cu negatively modulates flux through the pentose phosphate pathway by direct binding to phosphoribosylpyrophosphate synthetase (Prs), which synthesizes phosphoribosyl diphosphate (PRPP), a key metabolite that is used to synthesize the purine and pyrimidine nucleobases and nicotinamide dinucleotides

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