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Several approaches have been explored to enhance maturation of HLCs, including the formation of tissue-like 3D spheroids or organoids, use of extracellular matrix (ECM)-based hydrogels or scaffolds, coculture with endothelial cells or other hepatic cells, the addition of small molecules uncovered by screening, and overexpression of certain transcription factors, all of which are reviewed elsewhere (46)

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They are typically prescribed when oral supplements are ineffective or when rapid improvement of symptoms is required

Unlike their larger counterpartsproteinspeptides are more compact, allowing them to slip through molecular pathways with ease, delivering precise instructions to cells and tissues