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Participants were randomly assigned to receive 6 weeks supplementation with MitoQ or placebo in sequence, with a 2 weeks washout period between the two intervention phases

Quick Answer: Semaglutide is a synthetic medication engineered to mimic natural GLP-1 hormone but with a 7-day half-life compared to GLP-1's 1-2 minute duration, enabling practical therapeutic use

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10.1111/j.1365-2621.2012.03168.x 107 RavindraS.PriyankaS.PrakashBhanu.DubeyN

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However, arginine level depletion in patients sustained for about a week and returned to baseline level, suggesting that resistance on ADI-PEG20 may arise upon prolonged drug treatment [140, 141]