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doi: 10.1016/j.cell.2007.08.012

For hepatotoxic xenobiotics that directly affect the liver and produce hepatocellular necrosis, evidence of necrosis is usually apparent within forty-eight hours or earlier

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Chronic alcohol consumption increases the generation of reactive oxygen species (ROS) in hepatocytes, primarily through alcohol metabolism via alcohol dehydrogenase, cytochrome P450 2E1, and mitochondrial respiratory chain dysfunction [12, 42]